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Through our proprietary Topical by Design™ platform we develop targeted, topical treatments for inflammatory skin diseases and other conditions based on small molecules with well understood mechanisms of action. Using this technology, we site-selectively direct the conjugation of small polyethylene glycol (PEG) polymers to selected pharmacologically active compounds. This modification alters the pharmacological activity of the active compound to refine its target selectivity while also changing its physicochemical profile. The resulting new chemical entities (NCEs) are designed to permeate the skin or other targeted surfaces, such as the eye, the gastrointestinal tract or the respiratory tract, for highly localized delivery of the drug against the selected targets or pathway, while minimizing systemic exposure. By utilizing this targeted, topical approach, we create topical therapies that are specifically designed to be highly effective and suitable for chronic administration. Further, these drug candidates, if successfully developed and approved, may be eligible for regulatory exclusivity as NCEs. Our lead product candidates from our Topical by Design platform are SNA-120 and SNA-125.



Topical Photoparticle Therapy, uses precisely engineered silver particles to absorb laser light and convert the light energy into heat to facilitate local tissue injury. This process of targeting thermal injury to specific dermal tissues using laser light and an efficient light-absorbing material is called selective photothermolysis. In our current development programs with SNA-001, we are utilizing selective photothermolysis to treat acne vulgaris and to reduce unwanted light-pigmented hair. In the case of acne, SNA-001 targets one of the key structures implicated in the pathogenesis, or origin, of acne, the sebaceous gland. In the case of unwanted light or mixed pigmented hair, which cannot be removed with lasers alone, SNA-001 targets the hair follicle. We have designed patented photoparticles tuned to the three most used wavelengths of the most common dermatologic lasers to facilitate compatibility with the existing installed base.